Retooling Pap test to spot more kinds of cancer


WASHINGTON (AP) — For years, doctors have lamented that there's no Pap test for deadly ovarian cancer. Wednesday, scientists reported encouraging signs that one day, there might be.


Researchers are trying to retool the Pap, a test for cervical cancer that millions of women get, so that it could spot early signs of other gynecologic cancers, too.


How? It turns out that cells can flake off of tumors in the ovaries or the lining of the uterus, and float down to rest in the cervix, where Pap tests are performed. These cells are too rare to recognize under the microscope. But researchers from Johns Hopkins University used some sophisticated DNA testing on the Pap samples to uncover the evidence — gene mutations that show cancer is present.


In a pilot study, they analyzed Pap smears from 46 women who already were diagnosed with either ovarian or endometrial cancer. The new technique found all the endometrial cancers and 41 percent of the ovarian tumors, the team reported Wednesday in the journal Science Translational Medicine.


This is very early-stage research, and women shouldn't expect any change in their routine Paps. It will take years of additional testing to prove if the so-called PapGene technique really could work as a screening tool, used to spot cancer in women who thought they were healthy.


"Now the hard work begins," said Hopkins oncologist Dr. Luis Diaz, whose team is collecting hundreds of additional Pap samples for more study and is exploring ways to enhance the detection of ovarian cancer.


But if it ultimately pans out, "the neat part about this is, the patient won't feel anything different," and the Pap wouldn't be performed differently, Diaz added. The extra work would come in a lab.


The gene-based technique marks a new approach toward cancer screening, and specialists are watching closely.


"This is very encouraging, and it shows great potential," said American Cancer Society genetics expert Michael Melner.


"We are a long way from being able to see any impact on our patients," cautioned Dr. Shannon Westin of the University of Texas MD Anderson Cancer Center. She reviewed the research in an accompanying editorial, and said the ovarian cancer detection would need improvement if the test is to work.


But she noted that ovarian cancer has poor survival rates because it's rarely caught early. "If this screening test could identify ovarian cancer at an early stage, there would be a profound impact on patient outcomes and mortality," Westin said.


More than 22,000 U.S. women are diagnosed with ovarian cancer each year, and more than 15,000 die. Symptoms such as pain and bloating seldom are obvious until the cancer is more advanced, and numerous attempts at screening tests have failed.


Endometrial cancer affects about 47,000 women a year, and kills about 8,000. There is no screening test for it either, but most women are diagnosed early because of postmenopausal bleeding.


The Hopkins research piggybacks on one of the most successful cancer screening tools, the Pap, and a newer technology used along with it. With a standard Pap, a little brush scrapes off cells from the cervix, which are stored in a vial to examine for signs of cervical cancer. Today, many women's Paps undergo an additional DNA-based test to see if they harbor the HPV virus, which can spur cervical cancer.


So the Hopkins team, funded largely by cancer advocacy groups, decided to look for DNA evidence of other gynecologic tumors. It developed a method to rapidly screen the Pap samples for those mutations using standard genetics equipment that Diaz said wouldn't add much to the cost of a Pap-plus-HPV test. He said the technique could detect both early-stage and more advanced tumors. Importantly, tests of Paps from 14 healthy women turned up no false alarms.


The endometrial cancers may have been easier to find because cells from those tumors don't have as far to travel as ovarian cancer cells, Diaz said. Researchers will study whether inserting the Pap brush deeper, testing during different times of the menstrual cycle, or other factors might improve detection of ovarian cancer.


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Stock index futures point to second day of gains

LONDON (Reuters) - U.S. stock index futures pointed to a higher open on Wall Street on Thursday, with futures for the S&P 500, Dow Jones and Nasdaq 100 all around 0.2 percent higher at 0920 GMT.


European shares traded in sight of recent multi-month highs, with FTSEurofirst 300 <.fteu3> flat at 1,167.51 points by 0913 GMT <.eu> while Asian markets closed higher, supported by solid Chinese data <.t>.


China's export growth rebounded surprisingly sharply in December to a seven-month high, in a strong finish to the year for an economy that had slowed for seven quarters, but the spike may not herald an enduring recovery as global demand stays subdued.


U.S. stocks rose on Wednesday, rebounding from two days of losses, as investors turned their focus to the first prominent results of the earnings season. The Dow Jones industrial average <.dji> gained 61.66 points, or 0.46 percent, to 13,390.51. The Standard & Poor's 500 Index <.spx> rose 3.87 points, or 0.27 percent, to 1,461.02. The Nasdaq Composite Index <.ixic> gained 14.00 points, or 0.45 percent, to 3,105.81.


The nascent earnings season pauses, with no S&P 500 companies scheduled to report on Thursday.


Casual dining chain Ruby Tuesday Inc lowered the upper end of its full-year adjusted profit forecast after posting a wider-than-expected second-quarter loss. Shares fell after the bell.


U.S. asset manager BlackRock is to buy Swiss bank Credit Suisse's exchange-traded fund business for an undisclosed price.


A relatively thin U.S. data calendar features December trade data at 1330 GMT and budget figures at 1900 GMT.


Both the Bank of England and the European Central Bank are expected to announce on-hold policy ahead of U.S. market open, with the focus for the latter on the 1330 GMT press conference.


(Reporting By Toni Vorobyova; Editing by Catherine Evans)



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Swiss trains collide, 17 injured


NEUHAUSEN, Switzerland (Reuters) - Two Swiss trains collided on Thursday, injuring 17 people, none of them seriously, and closing the line near the German border, police said.


The two local trains, one travelling from Winterthur and the other from Schaffhausen, crashed just outside the Neuhausen station in northern Switzerland, not far from the German border.


Swiss railways said the line was closed and buses were carrying local passengers, while those travelling from Zurich to Stuttgart in Germany would be diverted via Basel.


Police spokeswoman Anja Schudel said 17 people had been injured and nine of them taken to hospital, but nobody was badly hurt. Everybody had been evacuated from the trains, which were carrying a total of 280 passengers, she said.


Swiss trains have a reputation for punctuality and safety, and fatal train accidents are rare.


The last major accident was in 2010. One passenger was killed and 42 were injured when one of the country's best-known tourist trains, the Glacier Express, derailed at the height of the summer holiday season.


(Reporting by Arnd Wiegmann and Emma Thomasson; Editing by Louise Ireland)



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Could Alex Jones’s “revolution” actually happen?






Piers Morgan had it easy. Radio show host and author Alex Jones threatened the rest of us with a ”revolution” if the government decides to confiscate guns from the homes and glove compartments of law-abiding Americans. It’s almost too easy to dismiss Jones as a fringe figure, especially since fringe ideas make their way into the mainstream with (exciting? alarming?) frequency these days. So let’s take him seriously.


Let’s accept his premise. Actually, let’s dismiss it first but then turn around and accept it for the sake of argument. The government has not the means nor the mechanism nor the credibility to confiscate 100,000 guns, much less 600,000,000. And those in the government doing the confiscating would be neighbors and relatives of the confiscatory victims: police officers, national guard members, Army reservists. Of course, Jones might say that their intent is bad enough. But “they” — the Obama administration, I assume — have no such intentions, and never did.






But OK. Let’s say that the government tries to confiscate guns and “the people” attempt to revolt.  No doubt that civil disobedience can spring up rather spontaneously and even be organized very quickly, but if rioting were to somehow break out in American cities, it would be isolated and theoretically containable. Organizing a “revolt” would require extensive planning, including the massive transportation of citizens from their homes to wherever the rally points were, a communications infrastructure, and leaders. The same Open Source culture that would make it difficult for the government to plan a confiscation in secret makes it just as unlikely for citizens to plan a feasible response to that confiscation in secret.


One of Jones’s obsessions, which, I confess, I share, is the militarization of the American homeland, and he is not promulgating a conspiracy here. The military has expanded its presence on American soil, and crucially, has expanded the way it is organized to respond to mass contingency events of any kind, including natural disasters and rioting. The U.S. Northern Command does receive intelligence briefings about domestic disturbances from the FBI and DHS, so commanders would be somewhat prepared to deploy troops. Thousands would come from the standing Army, but the bulk would be drawn from state National Guard detachments. It is exceedingly difficult to picture weekend warriors following blind orders en masse to detain or harm U.S. citizens when local police resources are stretched. The government has the power of command and control, but the people have the power of fellow-feeling. The government’s response to any real revolt would probably be quite restrained. There’d be too much attention paid to every movement of every tank to act harshly. The strategy to contain any “revolt” might therefore depend on a period of people letting out their energies and then returning to their normal business. 


Ah, but what if the government controls the communication nodes?  Well, corporations do; I assume Jones would have them immediately bend to a secret executive order shutting down serves and clouds and services like Twitter, but even if corporations agreed to do this, together, it would take days to get even a fraction of the telecom infrastructure offline. Maybe the government would order a mass power outage. But that’s why so many Americans have generators in the first place!  Although government “boards” comprising major telecom and infrastructure executives do exist, the most they’ve ever contemplated doing is to shut down a narrow slice of an infected communications node. These days, they’re focused on the cyber threat.  In the early days of civil defense planning, when there were a few television networks an AT&T had its monopoly, the threat of a government takeover of TV, radio and telephones was technically feasible. Today it is not. Actually, it does not make sense. What’s turned on really cannot be turned off.


But wait. if Jones’s “revolution” is to succeed, he needs to take over the government, because he’d need to dominate communications as well, unless he assumes that his movement would be organic and immune to arguments from elected officials asking for stability and calm.


An objective of anyone who wants to take over the government would be a seizure of the Emergency Broadcast System, which allows the President to speak to the nation through almost any mechanism of communication at any time. The EBS lives at Mt. Weather, the massive FEMA bunker in Virginia, but it can be activated and controlled from at least a dozen other places, including the briefcase of the Emergency Actions officer who travels with the President.  A coordinated violent action to seize control of this key portal would require an incredible amount of prior planning.


Assuming even that the government’s response to isolated-turned-mass rioting is uneven, the President would be able to address Americans anytime he wants. In theory, Jones’s followers could try to take over every broadcast entity in America, or could try and jam the broadcasts using sophisticated electronic warfare technology available to the military, but once again, the practicalities are not possible.


Because there will be no revolt over gun control, because there will not be and cannot be a mass confiscation of guns, playing with these ideas is fanciful and fodder for a sequel to Seven Days in May. Heck, we haven’t even addressed the FEMA concentration camps (which don’t exist).  But that isn’t to say that nothing discussed above will ever be relevant. It is much easier to imagine a small-scale revolt, a series of pre-planned violent protests against the powers that be, perhaps because the political system seems so non-responsive to the worries of people who listen to Alex Jones.  It would not take much to make Americans nervous about the government’s ability to restore law and order. And that frission itself is probably the most unknowable of all these factors.


Patriotic citizens aren’t supposed to speculate about these extremely unlikely events, but the government certainly thinks about them. So maybe we should too.


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Sandra Bullock Honored at People's Choice Awards for New Orleans Support









01/09/2013 at 10:45 PM EST







Sandra Bullock at the People's Choice Awards


Jason Merritt/Getty


Sandra Bullock took home big honors for her work in the Big Easy Wednesday night.

The People's Choice Awards crowned the Oscar-winning actress the favorite humanitarian for her career-spanning philanthropic efforts, including her dedication to New Orleans's Warren Easton Charter High School

"I'm not at all being modest when I say I'm not doing anything compared to what they do on a daily basis," Bullock, 48, told the crowd gathered at Los Angeles's Nokia Theatre.

Just six months after Hurricane Katrina hit in 2005, the actress showed her support by adopting the school, which sustained $4 million in damages during the storm. She donated hundreds of thousands of dollars for renovations, telling PEOPLE years later that she "felt such a profound need to do something for them."

Her generosity helped the charter school – the first public high school for boys in Louisiana – afford renovations, new band uniforms, athletic equipment and a new health clinic in a city that's close to her heart. After all, she adopted her son, Louis, from New Orleans in 2010 and also has a home in the Garden District.

She pointed to the tireless dedication of the school's students, teachers and tough principal. "I've seen her," she joked. "Yeah, you don't want to go into that office."

Bullock then gave a shout-out to her son, who was sick as home, she said.

"[The students] compete, but they never cut each other down," she added. "And all that happens not because it's easy, but because they do not allow themselves any other option than to succeed."

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Report: Death rates from cancer still inching down


WASHINGTON (AP) — Death rates from cancer are continuing to inch down, researchers reported Monday.


Now the question is how to hold onto those gains, and do even better, even as the population gets older and fatter, both risks for developing cancer.


"There has been clear progress," said Dr. Otis Brawley of the American Cancer Society, which compiled the annual cancer report with government and cancer advocacy groups.


But bad diets, lack of physical activity and obesity together wield "incredible forces against this decline in mortality," Brawley said. He warned that over the next decade, that trio could surpass tobacco as the leading cause of cancer in the U.S.


Overall, deaths from cancer began slowly dropping in the 1990s, and Monday's report shows the trend holding. Among men, cancer death rates dropped by 1.8 percent a year between 2000 and 2009, and by 1.4 percent a year among women. The drops are thanks mostly to gains against some of the leading types — lung, colorectal, breast and prostate cancers — because of treatment advances and better screening.


The news isn't all good. Deaths still are rising for certain cancer types including liver, pancreatic and, among men, melanoma, the most serious kind of skin cancer.


Preventing cancer is better than treating it, but when it comes to new cases of cancer, the picture is more complicated.


Cancer incidence is dropping slightly among men, by just over half a percent a year, said the report published by the Journal of the National Cancer Institute. Prostate, lung and colorectal cancers all saw declines.


But for women, earlier drops have leveled off, the report found. That may be due in part to breast cancer. There were decreases in new breast cancer cases about a decade ago, as many women quit using hormone therapy after menopause. Since then, overall breast cancer incidence has plateaued, and rates have increased among black women.


Another problem area: Oral and anal cancers caused by HPV, the sexually transmitted human papillomavirus, are on the rise among both genders. HPV is better known for causing cervical cancer, and a protective vaccine is available. Government figures show just 32 percent of teen girls have received all three doses, fewer than in Canada, Britain and Australia. The vaccine was recommended for U.S. boys about a year ago.


Among children, overall cancer death rates are dropping by 1.8 percent a year, but incidence is continuing to increase by just over half a percent a year. Brawley said it's not clear why.


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Global shares buoyed by Alcoa earnings, dollar gains on yen

LONDON (Reuters) - World shares staged a modest recovery from two days of losses on Wednesday after aluminum giant Alcoa opened the U.S. earnings season with an optimistic outlook for world demand.


However, with European and British central banks due to hold policy meetings on Thursday, the same day Spain will test demand for its debt and China releases its latest trade data, investors were in a cautious mood.


Alcoa, the largest aluminum producer in the United States, rose 1.3 percent in after-hours trade after it reported a fourth-quarter profit in line with Wall Street expectations and revenues that beat forecasts.


The results lifted Asian stock markets and pushed Europe's FTSE Eurofirst 300 index <.fteu3> up around 0.2 percent in early trade, leaving the MSCI world equity index <.miwd00000pus> up 0.1 percent. London's FTSE 100 <.ftse>, Paris's CAC-40 <.fchi> and Frankfurt's DAX <.gdaxi> were flat to 0.2 percent higher.


U.S. stock futures were up 0.15 percent, suggesting a firmer start on Wall Street. <.l><.eu><.n/>


Corporate profits are expected to be higher than the third quarter's lackluster results, but analysts' estimates are down sharply from where they were in October.


"Expectations are quite low going into the earnings season as we saw a lot of downward guidance in the past few months. There is potential for an upside surprise to come through," said Robert Parkes, equity strategist at HSBC Securities.


SOVEREIGN DEBT TEST


In European fixed income markets German Bund prices dipped slightly as investors prepared for the government's auction of 5 billion euros' worth of new five-year bonds following successful debt sales in Austria, the Netherlands and Ireland on Tuesday.


Investors were also looking ahead to Spanish and Italian bond auctions on Thursday for the new year's first test of market appetite for peripheral euro zone debt.


The Spanish auction could also provide clues on the timing of a much anticipated request by Madrid for fresh financial aid from the ECB. [ID:nL5E9C46KK]


The dollar meanwhile climbed against the yen, moving back towards a 2-1/2 year high hit last week, on expectations of a much bolder monetary easing from the Bank of Japan at its next meeting later this month.


The U.S. currency was up 0.7 percent at 87.61 yen, above a near one-week low of 86.82 hit earlier in Tokyo.


"No one is going to want to be short yen going into the BOJ meeting," said Derek Halpenny, European head of FX research at Bank of Tokyo-Mitsubishi.


Sources familiar with the BOJ's thinking told Reuters the central bank was likely to adopt a 2 percent inflation target at the meeting, double its current goal, and issue a statement with the government pledging to pursue bold monetary easing steps.


The BOJ will also consider easing monetary policy again this month, probably through a further increase in its 101 trillion yen ($1.2 trillion) asset buying and lending programme, the sources said.


The euro held steady against the dollar at $1.3080, with most analysts forecasting the European Central Bank will keep interest rates on hold on Thursday, though some believe rates will be cut later this year.


CHINA DEMAND EYED


Brent crude oil slipped around 0.3 percent to below $112 per barrel as the market awaited the latest trade data from China, the world's biggest energy consumer, due on Thursday.


"What we're seeing in the oil markets is the cautious sentiment playing up ahead of some key economic events this week," said Ker Chung Yang, senior investment analyst at Phillips Futures in Singapore.


However, iron ore jumped to its highest since October 2011, stretching a rally that has lifted prices by more than a third since December as China replenished stockpiles and as supply in the spot market remained limited.


Iron ore, a raw material used to make steel, has now risen 83 percent since falling to below $87 in September.


(Additional reporting by Nia Williams and Atul Prakash; Editing by Will Waterman)



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Exhausted Egyptians count cost of political turmoil


ZAGAZIG, Egypt (Reuters) - These days, craftsmen, shopkeepers and other inhabitants of the Egyptian Delta town of Zagazig are often too busy making ends meet to ponder why life seems to be getting harder every day.


But when, exhausted, they finally come home and sit down to their evening meal, conversations inevitably turn to growing hardship and the frightening prospect of cuts in food subsidies as the economy slides further into crisis.


With their patience already stretched after years of upheaval, Egyptians - from the capital Cairo to smaller towns like Zagazig - appear to be nearing the point where discontent could explode into a new wave of unrest.


"There is no security. There is nothing," said Soheir Abdel Moneim, a retired school teacher, as she hurried through an open-air market in Zagazig in search of vegetables she could afford.


"The pound is falling. Everything is more expensive. Is there anything that has not become more expensive?" she asked with a shrug, as traders on bicycles loaded with their wares dodged through the chaos of the market.


Nearby, a torn poster of President Mohamed Mursi beams from the wall of a crumbling brick house, with the words "Liars! Liars!" scrawled over his face.


The mood of growing nervousness is bad news for Mursi, who faces a parliamentary election in coming months, and a new round of political feuding that could pitch Egypt back into civil strife.


Egypt's economy, once strong and popular among investors, has been in tatters since the revolt of 2011 that ousted Hosni Mubarak and shook the country to its foundations.


Disagreements over a new national constitution late last year triggered violent protests, dealing another blow to the economy and eroding trust in Mursi's government.


A country where cuts in food subsidies have caused riots in the past now faces the risk of further upheaval as Mursi prepares to impose austerity measures in order to obtain a desperately needed $4.8 billion loan from the International Monetary Fund.


In Zagazig, people worry about the future.


Farouk Sarhan, the 74-year-old manager of a shop selling women's clothes, said sales were already down by almost 50 percent from just a few weeks ago.


"No one is selling or buying. I had more activity last year," he said, stubbing out a cigarette with a deep sigh in his tiny store lined with mannequins of veiled women.


"Customers are not buying as much as before because of the economic situation."


The price of fresh food often goes up in winter but shoppers in the Zagazig market said recent increases had been steep, with tomatoes and cauliflower about 50 percent dearer than at the start of the year.


WHAT NEXT?


Egypt has been on the ropes since investors and tourists fled after the revolt, when people rose up to demand their freedom and also an end to economic policies they said simply lined the pockets of the rich.


On the economic front, the picture remains grim, although Qatar's decision to lend Egypt another $2 billion has offered some respite.


Foreign reserves are dwindling and the pound has been hitting new lows daily. Food and raw materials from abroad have become more expensive, hurting businesses and families in a desert nation which relies on imports to feed itself.


As in other parts of Egypt, people in Zagazig see complex economic trends in terms of the daily hardships they must endure, and it is Mursi's government and his Muslim Brotherhood allies who get the blame.


"Mursi doesn't feel our grievances," said Emad, a man in his late 30s who sells traditional Egyptian clothes by the side of a dusty street. He said he had been forced to raise prices to cover rising costs, upsetting his customers.


Pointing to one of the black embroidered gowns, Emad said: "We used to sell this for 35 pounds ($5.40). Now it's 45 pounds. We didn't raise the prices. Traders did.


"Very few people are buying. I used to sell 50 pieces a day, and now I sell 15 or 20. Today I still haven't sold anything."


Reliable opinion polls are unavailable in Egypt and it is hard to gauge how widespread people's views are. But in Zagazig, most of those interviewed by Reuters echoed Emad's feelings.


Economists worry that continued turmoil could prompt people and businesses to convert their savings into dollars en masse - a risky process known as dollarisation which has caused trouble in many emerging market crises before.


But in Zagazig, people laughed at the idea, saying only the rich could afford to buy foreign currency. "Dollars?" asked Nabil, a local trader, as others burst into laughter. "Give me some dollars! Of course we don't have any!"


SUPPORT FOR MURSI


But some were prepared to give Mursi a chance.


In the nearby village of al-Adwa, where the future president grew up in the family of a local farmer, brick walls and fences were plastered with posters of Mursi.


A crowd of farmers standing by the side of a dirt track cutting through the village shook their fists and shouted "Mursi! Mursi!" when asked about their political views.


But even in Adwa, where Mursi appeared to enjoy rock-solid support, locals said sudden increase in taxes or abrupt cuts to fuel or food subsidies would cost him dearly.


"If that happens that would be the worst thing. What am I going to do as a farmer?" said Said Youssef, his hands black from working the land. "Where are we going to get the money?"


Another man, Aly Saber, 65, said fertilizer prices had gone up by 50 Egyptian pounds in the past year alone, making his business less profitable.


"Things are tough here in the rural areas," he said as others nodded in agreement. "Everything is becoming more expensive."


Mohamed Gamal, the 42-year-old owner of a tiny shop selling kitchen appliances, said business was so bad that he would sometimes go for days without a single customer.


"I import goods all the time. Prices have gone up by 10-40 percent since the revolution. It's gone up even more in recent weeks," said Gamal, who, Like Mursi, grew up in Adwa.


He said his neighbors were suspicious about why he had to keep raising his prices.


"People just don't believe me," he said, hunched over his desk, cigarette smoke swirling above stacks of unsold trays, cups and ironing boards. "They are not convinced why things are getting more expensive. I buy them, and they stack up."


($1 = 6.4809 Egyptian pounds)


(Writing by Maria Golovnina; Editing by Giles Elgood)



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NRA, video game makers to meet with Biden gun task force this week






WASHINGTON (Reuters) – The powerful gun lobby, the National Rifle Association, is slated to meet with Vice President Joe Biden as he considers recommendations on how to respond to a mass shooting last month in Newtown, Connecticut, the White House said on Tuesday.


After the Newtown school shooting, which President Barack Obama called the worst day of his presidency, he asked Biden to come up with a broad range of ideas to curb gun violence – ideas he will unveil in his annual State of the Union address, traditionally given in late January.






Obama has said he wants new gun control measures passed during the first year of his second term, but gun control is a divisive issue in the United States where the right to bear arms is enshrined in the Constitution.


Biden’s task force is examining legislation that would ban assault rifles, but is also looking at the role of violent movies and videogames in mass shootings and whether there is adequate access to mental health services.


Biden and his task force are slated to hold meeting this week with victims of gun violence, gun safety groups, hunting groups, and gun owners, White House spokesman Jay Carney told reporters.


“His group will also meet with representatives of the entertainment and video-game industries,” Carney said.


Health and Human Services Secretary Kathleen Sebelius will meet with mental health and disability advocates, and Education Secretary Arne Duncan is slated to meet with parent, teacher and education groups, Carney said.


The NRA has proposed armed guards in schools, an idea about which Obama has expressed skepticism.


The group’s top lobbyist, James J. Baker, will attend the task force meeting on Thursday, an NRA spokesman said.


“We are sending a representative to hear what they have to say,” NRA spokesman Andrew Arulanandam said in an e-mailed statement.


(Additional reporting by David Ingram; Editing by Sandra Maler and Jackie Frank)


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Brrr! Blake Lively & Ryan Reynolds Bundle Up for N.Y.C. Date Night















01/09/2013 at 06:00 AM EST







Ryan Reynolds and Blake Lively


Splash News Online


Baby, it's cold outside!

Blake Lively and Ryan Reynolds bundled up for dinner out at New York's Nobu 57 on Monday evening.

The couple – who live just outside the city in quaint Bedford, N.Y. – headed for the Robert De Niro co-owned restaurant) wearing their winter best.

"They were both dressed casually. [Ryan] had a knit had on and a few days worth of facial hair," an onlooker tells PEOPLE.

Upon entering the restaurant, Lively, who wore a "cute bright green puffer jacket," was "doing something with her phone," the source adds.


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